telbivudine resistance during prolong antiviral treatment after delivery (A prospective and open-label study for the efficacy and safety of telbivudine in pregnancy for the prevention of perinatal transmission of hepatitis B virus

Title: Telbivudine treatment started in early and middle pregnancy completely blocks HBV vertical transmission Authors: Weihui Sun ([email protected]) Zhao Shangfei ([email protected]) Ma Lei ([email protected]) Hao Anhua ([email protected]) Zhao Bo ([email protected]) Zhou Lin ([email protected]) Qu Qiaoyan ([email protected]) Song Mingquan ([email protected]) Xin Yongning ([email protected]) Version: 1 Date: 07 Dec 2016 Author’s response to reviews: Responses to the Reviewer Major comments from Editor 1. All clinical research papers submitted which involve human subjects must be accompanied by evidence of Institutional Review Board or Ethics Committee Review. Therefore, please insert the number of the IRB approval in the manuscript. Response: We thank the Editor for this comment. The Institutional Review Board of Qingdao Municipal Hospital had approved the study. However, there is no ID in the document. Approve document from IRB has been attached.